Products related to Mendelian:
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Mendelian Randomization : Methods for Causal Inference Using Genetic Variants
Mendelian Randomization: Methods For Causal Inference Using Genetic Variants provides thorough coverage of the methods and practical elements of Mendelian randomization analysis.It brings together diverse aspects of Mendelian randomization from the fields of epidemiology, statistics, genetics, and bioinformatics. Through multiple examples, the first part of the book introduces the reader to the concept of Mendelian randomization, showing how to perform simple Mendelian randomization investigations and interpret the results.The second part of the book addresses specific methodological issues relevant to the practice of Mendelian randomization, including robust methods, weak instruments, multivariable methods, and power calculations.The authors present the theoretical aspects of these issues in an easy-to-understand way by using non-technical language.The last part of the book examines the potential for Mendelian randomization in the future, exploring both methodological and applied developments. FeaturesOffers first-hand, in-depth guidance on Mendelian randomization from leaders in the fieldMakes the diverse aspects of Mendelian randomization understandable to newcomersIllustrates technical details using data from applied analysesDiscusses possible future directions for research involving Mendelian randomizationSoftware code is provided in the relevant chapters and is also available at the supplementary websiteThis book gives epidemiologists, statisticians, geneticists, and bioinformaticians the foundation to understand how to use genetic variants as instrumental variables in observational data. New in Second Edition: The second edition of the book has been substantially re-written to reduce the amount of technical content, and emphasize practical consequences of theoretical issues.Extensive material on the use of two-sample Mendelian randomization and publicly-available summarized data has been added.The book now includes several real-world examples that show how Mendelian randomization can be used to address questions of disease aetiology, target validation, and drug development
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Critical Doubt
They met in a war-torn city on the other side of the world and shared an anonymous night of passion. They didn't intend to meet again. Nor did they think they'd be reunited by sinister secrets... Five years later, FBI Agent Savannah Kane is headed to a small town in Georgia for the funeral of her best friend's husband. Going home is fraught with complications, but Savannah never imagined one of those would be Ryker Stone, the stranger she'd shared an unforgettable night with.Haunted by an ambush that took the lives of two men in his unit, Ryker now copes by living a solitary civilian life. Attending the funeral of yet another soldier, this one lost to a senseless accident, he is shocked to run into the beautiful stranger he has never forgotten.When another man in Ryker's former unit dies under suspicious circumstances, it's clear that someone is targeting his team. He's determined to get the truth; Savannah is just as determined to get answers for her friend. Neither wants to work with the other, and as they struggle with trust and attraction, the truth grows murkier...and more dangerous. Will finding answers reveal secrets neither one of them is ready to know? Don't miss this twisting, suspenseful, romantic page-turner by #1 New York Times Bestselling Author Barbara Freethy!
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How we Get Mendel Wrong, and Why it Matters : Challenging the narrative of Mendelian genetics
This book illustrates that the stereotypical representations of Gregor Mendel and his work misrepresent his findings and their historical context.The author sets the historical record straight and provides scientists with a reference guide to the respective scholarship in the early history of genetics.The overarching argument is twofold: on the one hand, that we had better avoid naïve hero-worshipping and understand each historical figure, Mendel in particular, by placing them in the actual sociocultural context in which they lived and worked; on the other hand, that we had better refrain from teaching in schools the naive Mendelian genetics that provided the presumed “scientific” basis for eugenics. Key FeaturesCorrects the distorting stereotypical representations of Mendelian genetics and provides an authentic picture of how science is done, focusing on Gregor Mendel and his actual contributions to scienceExplains how the oversimplifications of Mendelian genetics were exploited by ideologues to provide the presumed “scientific” basis for eugenicsProposes a shift in school education from teaching how the science of genetics is done using model systems to teaching the complexities of development through which heredity is materialized
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Questioning Qualitative Inquiry : Critical Essays
Is qualitative research in crisis? In Questioning Qualitative Inquiry Martyn Hammersley raises fundamental questions about the current state of qualitative social research.He examines some of the changes that have taken place within it over the past fifty years, suggesting that the move away from natural science as a model, and towards an appeal to literature and art, involves rejection of key principles that are essential to research of any kind. Hammersley argues that, in important respects, qualitative inquiry has not lived up to the claims originally made on its behalf, and that more recent developments have worsened the situation.Insufficient attention has been given to the problems surrounding leading ideas like thick description, analytic induction, and constructionism.The argument is pursued through discussion of the work of influential writers - such as Clifford, Geertz, Denzin and Lincoln - and by detailed examination of concrete issues, like the value of interview data, the rationales for discourse and conversation analysis, the role of rhetoric in research reports, and the nature of assessment criteria.At a time when qualitative inquiry is coming under renewed challenge in some quarters, the task of addressing the methodological problems it faces has become urgent. These essays on current developments and debates are essential reading for anyone interested in the future of qualitative research.
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What is Mendelian genetics?
Mendelian genetics is a set of principles established by Gregor Mendel in the 19th century that describes the inheritance of traits from parents to offspring. These principles include the concepts of dominant and recessive alleles, segregation, and independent assortment. Mendelian genetics forms the foundation of modern genetics and helps explain how traits are passed down through generations in a predictable manner.
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Which Mendelian rule fits?
The Mendelian rule that fits is the principle of segregation. This rule states that during the formation of gametes, the two alleles for a gene segregate from each other so that each gamete carries only one allele for each gene. This means that offspring receive one allele from each parent, and the combination of alleles determines the genetic traits of the offspring. This principle helps explain the inheritance patterns of single gene traits in offspring.
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What is the question about the 3rd Mendelian rule?
The question about the 3rd Mendelian rule, also known as the Law of Independent Assortment, is how different genes for different traits segregate independently of one another during the formation of gametes. This rule states that the inheritance of one trait is not dependent on the inheritance of another trait, as long as the genes controlling these traits are located on different chromosomes. This principle helps explain the variety of genetic combinations that can result from a single cross between individuals with different traits.
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What is the question regarding the 3rd Mendelian rule?
The question regarding the 3rd Mendelian rule, also known as the Law of Independent Assortment, is how genes for different traits segregate independently of one another during the formation of gametes. This rule states that the inheritance of one trait does not affect the inheritance of another trait. The question often revolves around understanding how genes located on different chromosomes assort independently during meiosis, leading to the inheritance of a unique combination of traits in offspring.
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Pragmatic Inquiry : Critical Concepts for Social Sciences
This book examines a range of critical concepts that are central to a shift in the social sciences toward "pragmatic inquiry," reflecting a twenty-first century concern with particular problems and themes rather than grand theory. Taking a transnational and transdisciplinary approach, the collection demonstrates a shared commitment to using analytical concepts for empirical exploration and a general orientation to research that favors an attention to objects, techniques, and practices.The chapters draw from broad-based and far-reaching social theory in order to analyze new, specific challenges, from grasping the everyday workings of markets, courtrooms, and clinics, to inscribing the transformations of practice within research disciplines themselves.Each contributor takes a key concept and then explores its genealogies and its circulations across scholarly communities, as well as its proven payoffs for the social sciences and, often, critical reflections on its present and future uses.This carefully crafted volume will significantly expand and improve the analytical repertoires or toolkits available to social scientists, including scholars in sociology or anthropology and those working in science and technology studies, public health, and related fields.
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Scientific Methods of Inquiry for Intelligence Analysis
Since 9/11, the needs of intelligence agencies as well as the missions they conduct have increased in number, size, and complexity.As such, government and private security agencies are recruiting staff to analyze the vast amount of data collected in these missions.This textbook offers a way of gaining the analytic skills essential to undertake intelligence work.It acquaints students and analysts with how intelligence fits into the larger research framework.It covers not only the essentials of applied research, but also the function, structure, and operational methods specifically involved in intelligence work.It looks at how analysts work with classified information in a security conscious environment as well as obtain data via covert methods.Students are left with little doubt about what intelligence is and how it is developed using scientific methods of inquiry. This revised edition of the popular text has been expanded and updated significantly.
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Critical Discourse Analysis : The Critical Study of Language
Bringing together papers written by Norman Fairclough over a 25 year period, Critical Discourse Analysis represents a comprehensive and important contribution to the development of this popular field. The book is divided into seven sections covering the following themes: language in relation to ideology and powerdiscourse in processes of social and cultural change dialectics of discourse, dialectical relations between discourse and other moments of social lifemethodology of critical discourse analysis research analysis of political discourse discourse in globalisation and 'transition' critical language awareness in education The new edition has been extensively revised and enlarged to include a total of twenty two papers.It will be of value to researchers in the subject and should prove essential reading for advanced undergraduate and postgraduate students in Linguistics and other areas of social science.
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Cancel Culture : A Critical Analysis
“Cancel culture” has become one of the most charged concepts in contemporary culture and politics, but mainstream critiques from both the left and the right provide only snapshots of responses to the phenomenon.Takinga media and cultural studies perspective, this book traces the origins of cancel practices and discourses, and discusses their subsequent evolution within celebrity and fan cultures, consumer culture, and national politics in the U.S. and China. Moving beyond popular press accounts about the latest targets of cancelling or familiar free speech debates, this analysis identifies multiple lineages for both cancelling and criticisms about cancelling, underscoring the various configurations of power associated with “cancel culture” in particular cultural and political contexts.
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What are the Mendelian inheritance rules?
The Mendelian inheritance rules are a set of principles that describe how genetic traits are passed from parents to offspring. These rules include the principles of dominance, segregation, and independent assortment. Dominance refers to the fact that one allele of a gene may mask the expression of another allele. Segregation describes how alleles separate and are randomly distributed into gametes during meiosis. Independent assortment states that alleles of different genes are inherited independently of each other. These rules form the basis of classical genetics and are fundamental to understanding inheritance patterns in organisms.
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What is the question about gene linkage and the 3 Mendelian rules?
The question about gene linkage and the 3 Mendelian rules likely pertains to how the principles of segregation, independent assortment, and dominance apply to genes that are physically linked on the same chromosome. Gene linkage can disrupt the principle of independent assortment, as linked genes are inherited together more often than not. This can lead to deviations from the expected Mendelian ratios in offspring. Understanding how gene linkage interacts with the 3 Mendelian rules is important for comprehending patterns of inheritance and genetic variation.
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What are the Mendelian laws in genetics?
The Mendelian laws in genetics refer to the principles of inheritance discovered by Gregor Mendel in the 19th century. These laws include the law of segregation, which states that each individual has two alleles for a trait, and these alleles separate during the formation of gametes. The law of independent assortment states that the inheritance of one trait is not dependent on the inheritance of another trait. Finally, the law of dominance states that one allele can be dominant over another, determining the phenotype of the organism. These laws laid the foundation for our understanding of genetic inheritance.
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What does the fourth Mendelian rule state?
The fourth Mendelian rule, also known as the law of independent assortment, states that the inheritance of one trait is independent of the inheritance of another trait. This means that the alleles for different genes are passed on to offspring independently of one another, and the assortment of one pair of alleles does not influence the assortment of another pair of alleles. This rule helps explain the variety of genetic combinations that can occur in offspring, contributing to genetic diversity within a population.
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